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Our Pipeline
Evopoint has built an exceptional development pipeline in our core therapeutics areas of interest, particularly oncology and infectious diseases.
Programs Target Indications
Preclinical Phase I Phase II Phase III NDA
XNW4107 BLI HABP/VABP

XNW4107 is a broad spectrum, best-in-class BLI inhibitor of the diazabicyclooctane (DBO) class for all three classes of A/C/D SBL. XNW4107 has successfully completed Phase III registration study in HABP/VABP and is currently at NDA stage.

XNW5004 EZH2 Lymphoma & Solid Tumor

XNW5004 is a best-in-class selective EZH2 inhibitor. In September 2024, XNW5004 was granted BTD (Breakthrough Therapy Designation) by CDE for relapsed or refractory peripheral T-cell lymphoma (PTCL). Pivotal studies in PTCL are ongoing.

XNW27011¹ CLDN18.2 Solid Tumors

XNW27011¹ and XNW28012 are topoi-based ADCs, both programs are currently in Phase III studies, with superior efficacy and safety observed across a broad range of solid tumors.

XNW28012 TF Solid Tumors

XNW27011¹ and XNW28012 are topoi-based ADCs, both programs are currently in Phase III studies, with superior efficacy and safety observed across a broad range of solid tumors.

XNW1011² BTK Autoimmune

XNW1011² is a next-generation BTK inhibitor. It can treat a variety of diseases, including B-cell-related hematological malignancies, primary membranous nephropathy, and IgA nephropathy, by targeting the B-cell receptor (BCR) signaling pathway.

XNW29016 PARG Solid Tumors

XNW29016 is a first-in-class PARG inhibitor entering Phase I clinical study. In preclinical studies, XNW29 has demonstrated robust efficacy, excellent PK properties and good safety profile.

XNW34017 Degrader Solid tumors

XNW34017 is a novel heterobifunctional degrader discovered through our TPD platform. The lead asset is currently in IND-enabling studies, with high oral bioavailability, outstanding in vivo efficacy, and manageable AE profile observed in preclinical studies

Programs Target Indications
XNW4107 BLI HABP/VABP
Preclinical Phase I Phase II Phase III NDA

XNW4107 is a broad spectrum, best-in-class BLI inhibitor of the diazabicyclooctane (DBO) class for all three classes of A/C/D SBL. XNW4107 has successfully completed Phase III registration study in HABP/VABP and is currently at NDA stage.

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Programs Target Indications
XNW5004 EZH2 Lymphoma & Solid Tumor
Preclinical Phase I Phase II Phase III NDA

XNW5004 is a best-in-class selective EZH2 inhibitor. In September 2024, XNW5004 was granted BTD (Breakthrough Therapy Designation) by CDE for relapsed or refractory peripheral T-cell lymphoma (PTCL). Pivotal studies in PTCL are ongoing.

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Programs Target Indications
XNW27011¹ CLDN18.2 Solid Tumors
Preclinical Phase I Phase II Phase III NDA

XNW27011¹ and XNW28012 are topoi-based ADCs, both programs are currently in Phase III studies, with superior efficacy and safety observed across a broad range of solid tumors.

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Programs Target Indications
XNW28012 TF Solid Tumors
Preclinical Phase I Phase II Phase III NDA

XNW27011¹ and XNW28012 are topoi-based ADCs, both programs are currently in Phase III studies, with superior efficacy and safety observed across a broad range of solid tumors.

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Programs Target Indications
XNW1011² BTK Autoimmune
Preclinical Phase I Phase II Phase III NDA

XNW1011² is a next-generation BTK inhibitor. It can treat a variety of diseases, including B-cell-related hematological malignancies, primary membranous nephropathy, and IgA nephropathy, by targeting the B-cell receptor (BCR) signaling pathway.

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Programs Target Indications
XNW29016 PARG Solid Tumors
Preclinical Phase I Phase II Phase III NDA

XNW29016 is a first-in-class PARG inhibitor entering Phase I clinical study. In preclinical studies, XNW29 has demonstrated robust efficacy, excellent PK properties and good safety profile.

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Programs Target Indications
XNW34017 Degrader Solid tumors
Preclinical Phase I Phase II Phase III NDA

XNW34017 is a novel heterobifunctional degrader discovered through our TPD platform. The lead asset is currently in IND-enabling studies, with high oral bioavailability, outstanding in vivo efficacy, and manageable AE profile observed in preclinical studies

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1、 Entered into an exclusive license agreement with Astellas Pharma Inc. (Tokyo Stock Exchange: 4503) for XNW27011, granting Astellas the exclusive rights to develop and commercialize XNW27011 worldwide excluding mainland China, Hong Kong, Macau, and Taiwan.

2、 Licensed the technology and applications of XNW1011 for autoimmune disease-related indications to SinoMab Bioscience Limited (HKEX: 3681), and entered into a global exclusive collaboration agreement with Everest Medicines (HKEX: 1952) to sublicense the global rights for the development and commercialization of XNW1011 in the field of renal diseases